Silicon Valley tech titan James Bell enlists Dr. Walter Wallace, an exceptional veteran surgeon with a controversial past, to run his state-of-the-art hospital with an ultramodern approach to medicine.
Malik and Zoe don't see eye to eye when it comes to using a revolutionary procedure involving spider silk to save a boy's crushed legs versus the safer route of amputation. Elsewhere, James, Walter and Talaikha care for a young woman in desperate need of a liver transplant who, to their surprise, is reluctant to accept a donation from her estranged father.
James wants to treat a police officer who suffered a brain injury in a car crash and lost all of his memories with a cutting-edge method to recode his brain; at the same time, an obese woman is given an appetite suppression sensor; and Zoe tries to erase security footage of her kiss with Malik.
When James' beloved elementary school teacher is diagnosed with an aggressive cancer, he tries to employ a risky robotic surgery to save her, an approach with which Walter disagrees. Also, a military veteran blinded in combat and riddled with guilt refuses Zoe and Talikha's high-tech treatment that could restore his vision.