With the knowledge that Valentine is alive and on the hunt for The Mortal Cup, the Institute is on high alert. Not wasting any time, Jace jumps into action and figures Clary’s memories are the key to finding Jocelyn and The Mortal Cup. Unfortunately, Clary’s memories were wiped leaving her without any recollection of this other life that could help her and the team. With only one other option remaining, Jace, Isabelle and a very reluctant Alec take Clary to the City of Bones to face the powerful Silent Brothers.
Meanwhile, Luke continues his search for Clary, and Simon tries to come to terms with his best friend’s new life.
With Simon being held captive at The Hotel DuMort, Clary pleads with Jace, Alec and Isabelle to help her rescue her best friend. As the team readies for the mission, Jace helps Clary learn more about her Shadowhunter powers, Isabelle turns to her favorite Seelie for Intel, and Alec begins to question Jace's motives and his place in their partnership.
Meanwhile, a very scared Simon gets very up close and personal with Camille, the leader of the vampire clan.
After getting a clue about who may have wiped Clary's memories, the crew hunts down the High Warlock of Brooklyn, Magnus Bane. With all of the warlocks in hiding from Valentine, the team must lure Magnus out with something he can't refuse - a killer party and something very valuable. But with emotions running high, more may come out of their meeting with Magnus than just the retrieval of Clary's memories.
Meanwhile, Simon doesn't seem to be himself after his recent Downworlder encounter.
Tensions escalate between Alec and Clary as they don't see eye to eye on the best way to hunt down Valentine. But when Jace and Isabelle are sent on an intel mission to the Seelies by Maryse Lightwood, Alec is put in charge of keeping Clary safe, much to both of their chagrin. With his hard-as-nails mother back in town and Clary's rule-breaking tendencies, Alec finds himself struggling to stick to the Claves rules while keeping his promise to Jace.
Meanwhile, the New York City Werewolf pack begins their hunt for Clary and The Mortal Cup.
With Luke in dire need of help, Jace, Clary and Simon take him to Magnus' lair in hopes of saving his life. Once there, the story of how Valentine came to be evil, and Jocelyn and Luke's past is revealed to Clary in hopes of triggering her memory of what happened to The Mortal Cup.
Meanwhile, Isabelle and Alec are tasked to restore their family name in the eyes of The Clave.
After piecing together the clues as to where her mother hid the Mortal Cup, Clary, Jace, Alec and Isabelle are on the clock to find its hiding place before anyone else. But with demons and Downworlders lurking everywhere, obtaining the Cup may not be as easy as they had hoped.
Meanwhile, as Simon's symptoms become increasingly worse, he fears he is turning into a vampire.