When Red is arrested and taken to a secret detention facility, Liz and the task force set out to save him before he disappears forever. At the facility, Red encounters a thief with whom he shares a complicated history.
As chaos ensues at the Factory, leaving the fate of Red and the task force unknown, Cooper struggles to rescue his team from the detention facility. It’s a race against time to prevent Luther Braxton attaining confidential information.
When an undercover CIA agent is kidnapped by a band of separatists in Uzbekistan, the task force sets a rescue mission in motion. Red informs Liz and Ressler that they are up against a very dangerous former associate.
When Red tips Liz off about the disappearance of a polygamous cult leader with dangerous shipping containers buried on his property, the task force sets out to investigate. Red utilizes his sources to appease Fitch’s last words and tries to track down his hidden safe.
A former paramour involves Reddington in a deadly game with a wealthy, powerful family dynasty whose ill-begotten fortune was amassed from an underground auction of human and material contraband. Meanwhile, Tom takes on a new mission.
When Agent Keen is questioned in court as a suspect in the murder of the DC Harbormaster, her unusual relationship with Red and their task force falls under scrutiny. Meanwhile, Red enlists Cooper and Ressler to locate "The Major," a dangerous former associate who is key in keeping Liz out of prison.
The task force tracks a provocative female Blacklister, a frame-up artist who targets the wealthy elite. Tom pleads for Liz's help. Red pressures Liz for the Fulcrum, claiming it's now a matter of life and death.
After decoding the information that is embedded in The Fulcrum, Red is determined to stop the imminent threat. Meanwhile, the task force discovers that deceased bodies of Chinese-American women are being smuggled out of the country under false identities. Liz continues to search for answers about her past after discovering a picture hidden in Red's secret flat.
Following intel from Red, the FBI find themselves one-step behind the most dangerous Russian Assassin, Karakurt, an enemy on U.S. soil. To avoid catastrophe, Liz and Ressler meet with Russian Counter-Intelligence who offer insight not only on Karakurt, but also on the identity of Liz’s mother. Cooper finds himself in a compromising position.
In the season finale Liz realizes she is being framed by The Cabal forcing Red to use his connections to help her clear her name. As Cooper receives shocking news, Ressler, Samar, and Aram must decide who on the task force can still be trusted.