In the aftermath of their journey to another planet, Director Phil Coulson and the rest of the team were driven more than ever to put an end to the Hydra organization. Little did they know that they were up against the deadliest threat they’ve ever faced – an extremely powerful Inhuman, Hive, who was transported back from Maveth in the body of their worst enemy, Grant Ward. The team was able to thwart and kill Hive and take down Hydra, but they are all still mourning the death of fellow agent and Inhuman Lincoln Campbell.
Coulson, Mack and Fitz try to locate and neutralize a rogue group looking to stop Inhuman Registration worldwide; Simmons and Dr. Radcliffe have only a short time to save May before she succumbs to her illness.
As Ghost Rider’s quest for vengeance brings him into an explosive confrontation with S.H.I.E.L.D., Coulson and Mack must rely on an unlikely ally in their time of desperate need; and Daisy reunites with a familiar face to stop the Watchdogs.