Ghost Whisperer explores the spiritual side of life and death as Melinda navigates among the dead and the living in her sometimes chilling, sometimes heart-rending and sometimes amusing attempts to act as an intermediary between the ghosts and those they haunt. Jim, her husband, worries about the emotional toll this work is taking on his wife as they embark on a new life together.
Andrea, her friend and business partner in their antique store, is fascinated by Melinda's talent. Melinda is somewhat reluctant to reveal her "gift" to new friend Delia Banks, a single mom who lives in Grandview, fearing the consequences of drawing her into this "unconventional" world. For her part, Melinda accepts her unique abilities as a blessing and sometime a curse, but always helps her clients--alive or dead--find emotional closure.