The fourth season of House premiered on September 25, 2007 and ended May 19, 2008. Having previously fired Chase, and with Foreman and Cameron quitting, House starts a competition between forty applicants for the vacant positions. He eventually narrows them down to seven, firing one each episode. In the episode "Games", he fires Amber "Cutthroat Bitch" Volakis, hiring Dr. Chris Taub, Dr. Lawrence Kutner and Dr. Remy "Thirteen" Hadley as his new team. Dr. Foreman rejoins the team after his dismissal from another hospital. Meanwhile, Amber begins a relationship with Wilson.
Interrupted by the 2007–2008 Writers Guild of America strike, the number of episodes was reduced to 16 instead of the planned 24. Executive producer Katie Jacobs explained that it was hard for the writers to finish the story arcs started during the season with eight episodes fewer. Season four also introduced seven actors to the cast; in addition to Jacobson, Penn and Wilde, who became regulars, Andy Comeau portrayed Travis Brennan, an epidemiologist; Edi Gathegi played Jeffrey Cole, a geneticist; Carmen Argenziano appeared as Henry Dobson, a former medical school admissions officer; and Anne Dudek portrayed Amber "Cut-throat Bitch" Volakis, an interventional radiologist. Each of the four departed the show after elimination, except for Volakis, who remained recurring until the finale, having started a relationship with Wilson.