The CSI team is shocked and saddened when, after working with Dr. Raymond Langston (Fishburne) on the "Dick & Jane" murders, Grissom announces that his time as a CSI has come to an end and offers Langston a permanent position on the CSI team.
When the CSIs are called to a murder scene at a familiar motel, Nick is thrown for a loop as he pieces together three separate murder investigations that all took place at the same establishment over the course of a year.
When a seasoned sky diver is paralyzed after free falling to earth when his parachute doesn't deploy, he turns out to be linked to the strange death-by-airborne-toxins of two wealthy men with ties to Iran.
When the producer of the reboot of a classic SF show is murdered at a Las Vegas science-fiction convention attended by both Hodges and Wendy (both, unknown to each other, fans of the original show), they find a connection with each other as the team investigates the crime.
A series of indeterminate deaths test the deductive powers of the CSI team, who fear that a public health emergency may be in the offing. Meanwhile, a friendly rivalry over who will win an upcoming bikini contest takes a deadly turn...