The team investigates the murder of Jason, a troubled computer geek working at a low-level casino support industry job who lures a colleague, Paulie, into a dangerous plan to make a working stiff's dream come true.
Two secretaries on holiday from Arizona attempt to steal a man's wallet and ATM pin number in a scam, and wind up dead in different locations. Meanwhile, the CSI team also investigates a disturbing medical mystery involving the dumping of human organs in a wildlife refuge.
Catherine and Detective Vartann are thrown together in a hotel room for 24 hours as they stake out a duo making drugs in the room next door. Meanwhile, Nick and Langston work a case that involves a fetish which has become big business in Vegas.